Free radical activity during percutaneous trans-luminal coronary angioplasty.

three centrifugations (gel I). Rather, we believe that successive centrifugation of large chylomicrons for 6 x 10' gmin results in their purification with loss of VLDL and small chylomicrons containing apo B100. The results demonstrate that purified large chylomicrons contain apo B-48, but do not contain apo B100 and that the apo B-1 00 in chyle is located in the small chylomicron and VLDL fraction. As remnants derived from apo B100-containing lipoproteins ultimately form atherogenic low-density lipoproteins, the results imply that large chylomicrons, which lack this apoprotein, are not as potentially atherogenic as small chylomicrons or VLDL containing apo B100. The skilled technical assistance o f Michael Avella and thc support of the Turkish Higher Education Committee and the British Heart Foundation are appreciated.